It was a day of upsets at the US Open on Wednesday led by former champion Andy Roddick who crashed out to Serbia’s Janko Tipsarevic.

Tipsarevic sealed his place in the third round with a fine 3-6, 7-5, 6-3, 7-6 (7/4) victory over the American, but the match will be most remembered for a prolonged outbust from Roddick at a line judge who called a foot fault at him.

Wimbledon finalist Tomas Berdych crashed out of the US Open in the first round, losing in straight sets to France’s Michael Llodra.

World number 35 Llodra just missed out on being seeded for the main draw, but proved why he was a player many of the seeds wanted to avoid with a 7-6 (7/3) 6-4 6-4 victory.

The 30-year-old left-hander had lost in the first round in 22 of his previous 36 grand slam singles events, but drove seventh seed Berdych to distraction with his serve and volley tactics.

Berdych was not the only seed to fall on day three, with 15th seed Ivan Ljubicic of Croatia beaten in four sets by 18-year-old American qualifier Ryan Harrison.

“The weather was my biggest enemy,” admitted 31-year-old Ljubicic.

“Throughout my career I struggled with the heat. I’m not really coping really well with that, and I tried all kind of different tactics to deal with it. I never find the right one.”

Asked if he would be in favour of the ‘heat rule’ - which allows players a 10-minute break after the second set - being applied to the men’s game as well as the women’s, Ljubicic joked: “I would be in favour of an indoor tour altogether, if you ask me.”

Dustin Brown reached the second round of a Grand Slam for the first time with a straight-sets win.

The Jamaican, considering changing nationality to British because of a lack of funding from his national association, defeated Ruben Ramirez Hidalgo 6-4 7-6 7-5 in New York.

Brown, who broke into the world’s top 100 in July but has since slipped back to 123rd in the rankings, will play Andy Murray in round two following his victory against Lukas Lacko.

In an all-American battle 20th seed Sam Querrey ousted Bradley Klahn 6-3 4-6 7-5 6-4 at Louis Armstrong Stadium.

Fourteenth seed Nicolas Almagro had to fight back from a set down to beat Potito Starace for the fifth time in his career.

Britain’s Andy Murray, who had to wait until the third day to play his first round match against Slovakia’s Lukas Lacko, needed just one hour and 51 minutes to complete a 6-3 6-2 6-2 victory on Arthur Ashe Stadium.